Desmopressin Powder Cas No.16679-58-6

We supply high-purity Desmopressin active pharmaceutical ingredient (API), manufactured specifically to meet stringent pharmaceutical application requirements. Its purity, determined by HPLC analysis, is no less than 98%. Produced within a GMP-compliant manufacturing system, rigorous quality standards are enforced from source control through to final packaging.

We are committed to providing customers with stable, compliant, high-quality APIs. Enquiries from buyers are welcome.

Desmopressin is a potent and selective analog of antidiuretic hormone. Its primary pharmacological action is antidiuresis. It significantly reduces urine output and increases urine osmolarity by enhancing water reabsorption in the kidneys. Compared to natural arginine vasopressin, it has minimal pressor activity and virtually no oxytocic activity, resulting in a higher safety profile and fewer side effects.

Desmopressin exerts its effect by specifically binding to vasopressin V2 receptors located on the basolateral membrane of principal cells in the renal collecting ducts. This binding activates an intracellular cAMP signaling pathway, which triggers the translocation and insertion of aquaporin-2-containing vesicles into the cell membrane. This dramatically increases the permeability of the collecting duct to water. Water is then reabsorbed back into the systemic circulation along the osmotic gradient, ultimately leading to concentrated urine and reduced urine volume.

Additionally, by engaging V2 receptors on vascular endothelial cells, it promotes the release of von Willebrand factor (vWF) and Coagulation Factor VIII from their storage sites into the bloodstream, thereby exerting a hemostatic effect.

When formulated into final dosage forms, Desmopressin API delivers two core therapeutic efficacies:

1. Potent Antidiuresis: Effectively controls symptoms of polyuria and polydipsia caused by a deficiency or insufficient secretion of antidiuretic hormone, normalizing urine output.

2. Significant Hemostatic Effect: Temporarily increases plasma levels of Factor VIII activity and circulating vWF, improving platelet function and consequently reducing bleeding time.

Pharmaceutical products manufactured products manufactured from Desmopressin API have clear and important clinical applications:

1. Treatment of Central Diabetes Insipidus:

Used as replacement therapy to control excessive urination and thirst in patients, serving as the standard treatment for this condition.

2. Treatment of Nocturnal Enuresis:

Used for managing primary nocturnal enuresis in children aged 6 years and older by reducing nighttime urine production.

3. Management of Bleeding Disorders:

● Used in patients with mild Hemophilia A to control or prevent bleeding during minor surgical procedures or in episodes of minor bleeding.

● Used in patients with Type I von Willebrand Disease to elevate coagulation factor levels and improve hemostasis during minor surgery or in the presence of bleeding.

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