Cetrorelix Acetate Powder Cas No. 120287-85-6
Product Source: Synthetic
Product content: ≥ 98%
CAS Number: 120287-85-6
Detection Method: HPLC
Active Ingredient: Cetrorelix Acetate
Product shape: White to off white
Product Mesh: 80-120 mesh
Product Uses: Assisted reproductive technology (ART), gynecological disease treatment, research purposes
Product Packaging: Lyophilized powder: Usually packaged in glass ampoules or aluminum foil bags, with the capacity of each bottle/bag customized according to requirements (such as 1mg, 5mg, 10mg, etc.).
Liquid form: Requires sterile injection vials or vials, with solvent packaged separately.
Product Storage: Usually stored in a light-proof, sealed environment at 2-8°C.
Shelf Life: When unopened and stored at 2-8°C in a light-proof manner, the shelf life is typically 2-3 years.
Products Description
Cetrorelix Acetate Powder is a synthetic gonadotropin-releasing hormone (GnRH) antagonist with a chemical structure of a cyclic decapeptide derivative. It competitively binds to the GnRH receptor in the anterior pituitary gland, inhibiting the release of endogenous luteinizing hormone (LH) and follicle stimulating hormone (FSH), thereby regulating reproductive hormone levels. This compound is usually provided in the form of freeze-dried powder and needs to be dissolved before use.
Pharmacological effects
Cetrorelix Acetate Powder is a Gonadotropin-Releasing Hormone (GnRH) Antagonist. It works by competitively binding to and blocking GnRH receptors in the pituitary gland, leading to a dose-dependent suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion. This is crucial in ART for inhibiting the endogenous LH surge and preventing premature ovulation. Its suppressive effect is rapid and reversible, with pituitary function recovering quickly after the drug is stopped.
Mechanism of action
Cetrorelix Acetate Powder, also commonly known as Cetrorelix, is an effective progesterone hormone-inhibiting hormone (LH-RH) receptor antagonist. It can control ovarian stimulation, prevent premature release of immature follicles, and facilitate conception. Therefore, it is often used as an injectable cetrorelix preparation.
Intended for
Female patients receiving controlled ovarian stimulation (such as infertility treatment). Patients with gynecological diseases that require hormone regulation, such as endometriosis.
The efficacy and application scenarios of the product
|
Effect Type |
Specific Description |
Primary Application Context |
|
Core Efficacy |
Prevents premature ovulation during Controlled Ovarian Stimulation (COS) |
Ovarian stimulation cycles in Assisted Reproductive Technology (e.g., IVF) |
|
Key Action |
Inhibits the Luteinizing Hormone (LH) surge |
Ensures sufficient time for follicle maturation, improving the number and quality of eggs retrieved |
|
Additional Benefit |
Reduces the risk of Ovarian Hyperstimulation Syndrome (OHSS) |
When using gonadotropins for ovarian stimulation |
|
Pharmacological Property |
Competitively blocks pituitary GnRH receptors, rapidly inhibits the secretion of LH and FSH; effects are reversible after discontinuation |
Treatment scenarios requiring rapid suppression and recovery of the reproductive axis function |
|
Other Potential Applications |
May improve endometriosis-related dysmenorrhea, regulate hypothalamic-pituitary-ovarian axis dysfunction, promote spermatogenesis (Note: These are not mainstream uses) |
Investigational treatment for related conditions or male fertility improvement (requires strict medical evaluation) |
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