Acetyl Hexapeptide-8 API CAS 616204-22-9
CAS Number: 616204-22-9
Synonyms: Argireline, Acetyl Hexapeptide‑8
Source: Synthetic peptide
Assay / Specification: ≥99% (HPLC)
Testing Method: HPLC
Active Ingredient: Acetyl Hexapeptide‑8
Mesh: 80–100 mesh
Appearance: White to off-white crystalline powder
Packaging: 1g / 10g / 100g / 500g / 1kg aluminum foil bag；25kg cardboard drum
Storage: Cool, dry, sealed, away from light & moisture
Shelf Life: 24 months under proper storage
Acetyl Hexapeptide-8 API | CAS 616204-22-9 | SNARE Complex Modulator
Acetyl Hexapeptide-8 (commonly referred to as Argireline) is a high-purity synthetic peptide designed to attenuate expression lines by competing for a position in the SNARE complex. As a leading Acetyl Hexapeptide-8 powder manufacturer, Xi'an Tihealth Biotechnology Co., Ltd. prioritizes the biophysical reality of transdermal delivery. We provide a cosmetic-grade API with ≥ 99.0% purity, engineered for maximum stability, ensuring no ionic collapse in Carbomer systems and zero immunogenic deletion sequences.
⚠️ CRITICAL REGULATORY NOTICE & DISCLAIMER (RUO)
Professional Manufacturing & Research Use Only: This product is supplied exclusively as a raw material powder for professional laboratory research and industrial cosmetic manufacturing. It is NOT a finished cosmetic or medicinal product and is strictly prohibited for direct human use or consumption in its current concentrated form. Xi'an Tihealth assumes no liability for unauthorized applications.
Biophysical Mechanism & Quality Standards
Acetyl Hexapeptide-8 modulates muscular contractions by competitively inhibiting the synaptic protein complex. To achieve dermal impact, R&D labs must utilize penetration enhancers (e.g., liposomes) to fluidize the stratum corneum, as passive diffusion for a molecule of this size requires specialized delivery vehicles.
- HPLC Purity ≥ 99.0%: Strict elimination of "deletion sequences" to prevent immunogenic reactions and inflammatory erythema in sensitive cosmetic formulations.
- Residual Acetic Acid ≤ 8.0%: Engineered to prevent the ionic collapse of Carbomer networks, ensuring absolute viscosity stability on the factory floor.
- Processing Mandate: Formulators must strictly adhere to cold-process manufacturing (Temp < 35°C). Maintain the final formulation pH between 5.5 and 6.0 for optimal peptide bond integrity.
API Technical Data Sheet
| Analytical Parameter | Xi'an Tihealth Specification |
|---|---|
| Product Name | Acetyl Hexapeptide-8 |
| CAS Number | 616204-22-9 |
| Molecular Formula | C34H60N14O12S |
| Molecular Weight | 889.0 g/mol |
| Peptide Purity (HPLC) | ≥ 99.0% |
| Appearance | White lyophilized powder |
Packaging & Storage: Supplied in 1g, 10g, 100g sealed vials or custom bulk packaging. Must be stored in a cool, dry environment at 2-8°C. Long-term storage at -20°C is recommended to preserve sequence integrity.
Global R&D Procurement FAQ
As a concentrated API powder, it has not been neutralized, buffered, or stabilized for direct contact with human tissue. Direct application may cause severe irritation, pH-related burns, or systemic toxicity due to high concentration. It is a chemical precursor, not a retail product.
Can we use this API for professional microneedling research?
Yes, provided the formulation is prepared in an aseptic environment. Our microbial limit of ≤ 100 cfu/g is specifically controlled to accommodate research where the skin barrier is bypassed, significantly reducing the risk of inflammatory infections.
What documentation is provided for regulatory audits?
Xi'an Tihealth provides a comprehensive technical dossier for every batch. This includes the Certificate of Analysis (COA), explicit HPLC purity chromatograms, Mass Spectrometry (MS) data, and MSDS to support compliance with local regulatory frameworks.
Xi'an Tihealth Biotechnology Co., Ltd. Compliance Statement: Raw material API. For professional laboratory and industrial manufacturing use only.
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