Elamipretide 99% Cas No.736992-21-5
Product Alias: SS-31, MTP-131, Bendavia
Specification: ≥99%
CAS No.: 736992-21-5
Molecular Formula: C₃₂H₄₉N₉O₅
Molecular Weight: 639.8 g/mol
Analysis Method: HPLC
Active Ingredient: Elamipretide
Product CharacteristicsProduct Characteristics: White to off-white powder
Packaging: Various specifications available (mg, g, kg), customizable
Storage Condition: -20°C ± 5°C, stored in a dry place, protected from light
Shelf Life: 36 months
Declaration of Use: This product is intended for industrial use or scientific research only.
Elamipretide API Powder | CAS 736992-21-5 | Mitochondria-Targeted Peptide
Elamipretide (also recognized in literature as SS-31 or Bendavia) is a first-in-class, synthetic tetrapeptide engineered to selectively target and restore mitochondrial bioenergetics. Xi'an Tihealth Biotechnology Co., Ltd. supplies this advanced active pharmaceutical ingredient (API) with a strictly verified HPLC purity of ≥ 99.0%. Characterized by its unique alternating aromatic-cationic structural motif, our Elamipretide API effortlessly crosses cell membranes to localize at the inner mitochondrial membrane (IMM). It is the premier raw material for groundbreaking R&D targeting primary mitochondrial myopathies and neurodegenerative disorders.
⚠️ REGULATORY COMPLIANCE & STRICT RESEARCH USE ONLY (RUO)
Industrial R&D Application: This high-purity Elamipretide is supplied strictly as a raw material API powder for professional laboratory research, biopharmaceutical formulation development, and preclinical in-vitro/in-vivo assays. It is NOT a finished pharmaceutical drug and is explicitly prohibited for direct administration to humans or animals.
Chemical Profile & Specification Parameters
| Analytical Parameter | Xi'an Tihealth Specification |
|---|---|
| Generic Name | Elamipretide (SS-31) |
| CAS Number | 736992-21-5 |
| Molecular Formula | C32H49N9O5 |
| Molecular Weight | 639.8 g/mol |
| Peptide Purity (HPLC) | ≥ 99.0% |
| Appearance | White to off-white lyophilized powder |
Storage & Handling Protocols: Preserve in tight, light-resistant containers. Store strictly at -20°C in a desiccated environment. Ensure the vial reaches room temperature before opening to avoid moisture condensation, which can rapidly degrade the short peptide sequence.
Cardiolipin Targeting & Mechanism of Action
Unlike traditional systemic antioxidants, Elamipretide functions as a targeted structural stabilizer within the mitochondria, specifically binding to cardiolipin, a signature phospholipid of the inner mitochondrial membrane (IMM):
- ETC Supercomplex Stabilization: By electrostatically and hydrophobically associating with cardiolipin, Elamipretide restores the structural architecture of the electron transport chain (ETC) supercomplexes, directly optimizing ATP synthesis efficiency in metabolically compromised cells.
- ROS Source Mitigation: Instead of merely scavenging free radicals, it curtails the generation of Reactive Oxygen Species (ROS) at their source by preventing electron leakage during mitochondrial respiration.
- Apoptosis Inhibition: Cardolipin stabilization actively prevents cytochrome c peroxidase activity and the pathological opening of the mitochondrial permeability transition pore (mPTP), thereby halting downstream apoptotic cascades.
Therapeutic & Orphan Drug R&D Applications
Xi'an Tihealth provides this highly specialized API to propel advanced clinical and preclinical research in the following critical domains:
- Primary Mitochondrial Myopathies: Core investigational API for severe mitochondrial dysfunctions, notably including Barth Syndrome (which involves pathological cardiolipin remodeling) and Leber's Hereditary Optic Neuropathy (LHON).
- Cardiovascular Therapeutics: Extensively researched for mitigating ischemia-reperfusion injury following myocardial infarction and improving bioenergetics in chronic heart failure models.
- Neurodegenerative & Ophthalmic Research: Utilized in preclinical models to explore protective efficacies against Alzheimer's disease pathology and age-related macular degeneration (AMD).
API Procurement & Technical FAQ
Elamipretide belongs to the Szeto-Schiller (SS) class of peptides. Its sequence features an alternating aromatic-cationic motif. This unique structural design allows it to freely penetrate plasma membranes and selectively accumulate on the inner mitochondrial membrane independently of the mitochondrial membrane potential.
To support strict academic and pharmaceutical research, Xi'an Tihealth provides a comprehensive analytical package with every commercial batch. This includes a detailed Certificate of Analysis (COA), explicit HPLC purity chromatograms (≥ 99.0%), and Electrospray Ionization Mass Spectrometry (ESI-MS) to confirm the exact molecular mass (639.8 Da).
Yes. Utilizing optimized Solid-Phase Peptide Synthesis (SPPS) and advanced HPLC purification networks, we seamlessly support our partners from early-stage mg-scale screening to robust kg-scale bulk API supply for advanced clinical trial phases.
Xi'an Tihealth Biotechnology Co., Ltd. Quality Commitment: GMP-aligned pharmaceutical API intended strictly for laboratory analysis and formulation R&D. Not for direct clinical administration.
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