Deoxycholic Acid Powder Cas No.83-44-3
Product Source: Prepared by bovine bile hydrolysis or produced by gut microbiota metabolism (secondary bile acid)
Product Specification: ≥99%
CAS No.: 83-44-3
Molecular Formula: C₂₄H₄₀O₄
Molecular Weight: 392.57
Testing Method: HPLC
Active Ingredient: Deoxycholic Acid
Product Characteristics: White to grayish-white crystalline powder
Product Packaging: 1kg/bag; 25kg/drum
Storage Conditions: Store in a cool, dry place after sealing
Shelf Life: 24 months
Products Description
High-Purity Deoxycholic Acid API | CAS 83-44-3
Deoxycholic Acid (CAS No. 83-44-3), a naturally occurring secondary bile acid, is a highly potent cytolytic agent. Manufactured under stringent cGMP-compliant standards, Xi'an Tihealth supplies pharmaceutical-grade Deoxycholic Acid powder engineered specifically for advanced clinical formulations. With an HPLC-validated assay of ≥99.0%, our API undergoes rigorous purification to strictly control endotoxins, heavy metals, and related bile acid impurities. It serves as the gold-standard active pharmaceutical ingredient for the formulation of targeted localized adipocytolytic injectables (fat-dissolving injections) and critical biochemical research, delivering uncompromised safety and lot-to-lot consistency.
Technical Data Sheet (TDS) & Core Specifications
To meet the stringent regulatory requirements for subcutaneous injectable formulations, our Deoxycholic Acid undergoes exhaustive analytical testing:
| Testing Item | Specification (USP/EP Standard) |
|---|---|
| Chemical Name | 3α,12α-Dihydroxy-5β-cholan-24-oic acid |
| Assay (HPLC, Dried Basis) | ≥ 99.0% |
| Appearance | White or almost white crystalline powder |
| Related Bile Acids | Strictly controlled (Cholic Acid, Chenodeoxycholic Acid limits verified) |
| Bacterial Endotoxins | Strictly monitored for Injection-Grade compliance |
| Viral & Prion Safety | TSE/BSE Free Certified |
Pharmacological Mechanism: Adipocytolysis
Deoxycholic acid exerts its primary therapeutic effect through non-selective cytolytic action when administered via localized subcutaneous injection:
- Cell Membrane Disruption: Functioning as a potent biological detergent, it rapidly intercalates into the lipid bilayer of adipocytes (fat cells), disrupting membrane integrity and causing irreversible cell lysis (necrosis).
- Lipid Clearance & Inflammation: The lysis of adipocytes releases cellular lipids and debris into the interstitial space, triggering a mild, localized inflammatory response. Macrophages are recruited to the site to phagocytize and permanently clear the lipid debris and cellular remnants.
- Fibroblast Activation: The subsequent tissue remodeling phase stimulates local fibroblast activity, promoting neocollagenesis (new collagen formation) that aids in tissue retraction and skin firming in the treated area.
Formulation & Pharmaceutical Applications
- Aesthetic Injectables: The indispensable active pharmaceutical ingredient for manufacturing generic submental fat-reducing injectables (adipolytic solutions).
- Biochemical R&D: Extensively utilized in laboratory settings as an effective cell lysis buffer component and for the solubilization/isolation of membrane-bound proteins.
- Vaccine & Liposome Manufacturing: Acts as a critical stabilizing and solubilizing excipient in specific complex liposomal drug delivery systems and viral vaccine formulations.
Regulatory Compliance Notice: Deoxycholic Acid API is supplied strictly for B2B industrial formulation, pharmaceutical compounding, and R&D. Downstream manufacturers must ensure appropriate sterilization and regulatory approvals before commercializing injectable end-products.
Frequently Asked Questions (FAQ)
To meet the highest safety standards for injectable formulations and eliminate the risk of transmissible spongiform encephalopathies (TSE/BSE), Xi'an Tihealth provides synthetically derived or rigorously highly-purified Deoxycholic Acid that is fully certified TSE/BSE free.
Does this API meet the microbiological limits for injectables?
Yes. Our advanced purification process effectively controls bacterial endotoxins and microbial limits. However, as an API, it requires terminal sterilization (e.g., sterile filtration) by the downstream formulation manufacturer to produce finished injectables.
Do you provide DMF documentation and full COA?
Absolutely. We provide comprehensive technical packages, including the Certificate of Analysis (COA), Method of Analysis (MOA), MSDS, and stability testing data to support your QA/QC departments and regulatory drug submissions.
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