Pharmaceutical-Grade Deep-Sea Salmon PDRN (DNA Sodium) Powder
Source: Deep-Sea Salmon (different from ordinary deep-sea trout)
Assay Standard: ≥ 99.0%
Extraction Part: Salmon milt / sperm sacs
Molecular Weight Fragments: 80–100bp, 200–250bp
Protein Impurity Limit: ≤ 1.0%
Storage Condition: Refrigerate at 2–8℃
Shelf Life: 24 Months
Core Biological Mechanisms
1. A2A Adenosine Receptor Activation
PDRN specifically targets and activates the A2A receptor pathway. This crucial interaction triggers a cascade of restorative responses: it actively inhibits inflammatory markers, upregulates essential growth factors, and promotes angiogenesis (new blood vessel formation). This mechanism enables comprehensive tissue regeneration and damage repair.
2. The Nucleotide Salvage Pathway
Once metabolized, the bases and nucleosides generated from PDRN are efficiently recovered through the biochemical salvage pathway. These fragments are directly reintegrated into cellular DNA, rapidly reactivating normal cellular proliferation and significantly accelerating internal wound healing and tissue reconstruction.
In-Vitro Assays & Clinical Validation
Fibroblast & Collagen Stimulation
In cellular assays using Human Skin Fibroblasts (HSF), our PDRN demonstrated superior biological activity. Relative cell proliferation increased to 104.80%. Furthermore, it significantly promoted the secretion of extracellular matrix proteins, boosting Type I Collagen to 114.42% and Type III Collagen to 116.70%.
Potent Anti-Inflammatory Action
In RAW264.7 macrophage models, our standardized PDRN extract dramatically suppressed pro-inflammatory cytokines, reducing IL-6 secretion to 77.90% and TNF-α to 85.00%. Concurrently, it upregulated the anti-inflammatory cytokine IL-10 to 131.20%, establishing excellent anti-inflammatory efficacy.
Dermatological Clinical Efficacy
Randomized double-blind clinical trials validate profound anti-aging effects. After 28 days of application, dermal density increased by 8.67%. Specific evaluations showed a reduction in crow's feet area by 10.31%, under-eye wrinkles count by 27.06%, and tear trough volume by 18.11%.
Sunburn Repair & Acne Control
Under UV-induced damage models, a 0.5% PDRN solution decreased Trans-Epidermal Water Loss (TEWL) by 14.3% and reduced skin redness (a* value) by 20.33%. In acne-prone subjects, the acne area ratio dropped by a remarkable 59.23% alongside a 16.81% decrease in comedones.
Pharmaceutical-Grade Quality Control
Comprehensive PDRN Grade Specifications
| Product Form | Key Specifications & Features | Target Grade / Application |
|---|---|---|
| 1. Powder | Protein Content < 1.0% (Tested < 0.05%) | Cosmetic Grade / Food Grade |
| 2. Lyophilized (Freeze-Dried) | Zero Protein, Deionized | Premium Cosmetic Grade |
| 3. Powder (Ultra-Pure) | Endotoxin < 0.5EU (Customizable to < 0.05EU) | Class II/III Medical Device Grade |
| 4. Liquid | Ready-to-use Aqueous PDRN Solution | Versatile Manufacturing Formulation |
Formulation Compatibilities & Storage
Ensuring Maximum Biological Activity
Dissolution: Soluble in water at room temperature. We recommend adding PDRN slowly during magnetic stirring to prevent agglomeration.
Incompatibilities: Strictly avoid strong oxidizers, highly active substances, cationic salts, hydrogen peroxide, high concentrations of alcohol, tannic acid, fruit acids, and citric acid. Prolonged high temperatures are prohibited.
Storage: To guarantee structural integrity, store sealed in a cool, dark place (refrigerated at 2-8°C). The verified shelf life is 2 years.
Formulation & Procurement FAQ
Q1: What is the specific molecular weight of your PDRN API?
Through a patented molecular weight control process, our PDRN is precisely concentrated at 200-250bp (138-165KDa). This concentrated distribution ensures stronger fluorescence intensity in nucleic acid electrophoresis, highly consistent viscosity, and optimal biological efficacy.
Q2: How do you control protein residue to prevent allergic reactions?
We utilize an advanced purification process that reduces protein residue to below 0.05%. Validated via BSA protein electrophoresis, our PDRN shows no visible protein bands even at high loading volumes of 800µg, minimizing immunogenicity and allergy risks to the absolute extreme.
Q3: What are the formulation incompatibilities for PDRN?
Formulators must avoid strong oxidizing agents, highly reactive substances, cationic salts, hydrogen peroxide, high concentrations of alcohol, tannic acid, fruit acids, and citric acid. Prolonged exposure to high temperatures is also strictly prohibited.
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