Leech Extract
Source: Poecilobdella manillensis
Appearance: reddish brown
Mesh size: Fineness of 100 mesh
Odor: No odor, fishy smell
Moisture content: not exceeding 5%
Content: The hirudin content of this product is greater than 300ATU/g
Specifications: 50g, 100g, 200g, 500g, 1kg aluminum foil bag packaging
API Technical Data Sheet (TDS)
Derived from premium Poecilobdella manillensis, our Leech Extract is a highly bioactive raw material recognized for its exceptional concentration of natural Hirudin. Xi'an Tihealth utilizes advanced purification technologies to deliver an ingredient that exceeds standard pharmacopeia requirements, making it ideal for cardiovascular research, anti-aging cosmetics, and high-end nutraceuticals.
| Product Name | Leech Extract Powder (Natural Hirudin) |
| Botanical/Animal Source | Poecilobdella manillensis |
| Key Active Ingredient | Natural Hirudin (Polypeptide) |
| Biological Activity | 150 ATU/g - 3000 ATU/g (Inhibition of thrombin - Customizable) |
| Molecular Characteristics | Low molecular weight polypeptide; high permeability compared to standard heparin. |
| Appearance | Light Yellow to Brown Fine Powder (Uniform, no visible impurities) |
| Extraction Methods | 1. Cryogenic Salivary Secretion Isolation 2. Whole Body Enzymatic Hydrolysis |
| Safety Profile | High biocompatibility; standardized to minimize hemorrhagic side effects typical of synthetic anticoagulants. |
Pharmacological & Formulation Advantages
Xi'an Tihealth's Leech Extract offers unmatched advantages for professional B2B formulations
1. Unsurpassed Anticoagulant Potency
Sourced from Poecilobdella manillensis, the natural hirudin content yields anticoagulant activity up to 14 times higher than that of Japanese medical leeches and 73 times higher than broad-bodied golden leeches.
2. Advanced Extraction Versatility
We offer distinct grades based on your R&D needs:
• Medical-grade crude hirudin (isolated via chemical induction and salivary purification).
• Standardized whole-leech extract (processed via targeted enzymatic hydrolysis for broader nutritional peptide profiles).
3. High Thrombolytic Permeability
Unlike heparin, the low molecular weight of hirudin does not require antithrombin III as a cofactor, allowing it to penetrate and dissolve deep within blood clots with exceptional efficacy.
Key Biological Functions
1. Thrombin Inhibition & Anticoagulation:
Hirudin is one of the most potent natural inhibitors of thrombin. It binds directly to thrombin, supporting formulations designed to inhibit platelet aggregation and reduce blood viscosity without relying on endogenous cofactors.
2. Targeted Anti-Inflammatory Modulation:
Beyond hirudin, the specialized nutritional peptides in our extract effectively modulate inflammatory pathways, providing robust support for topical and internal anti-inflammatory formulations.
3. Microcirculation Enhancement:
By promoting localized vascular dilation and improving peripheral blood flow, the extract serves as a critical ingredient in resolving stasis and supporting optimal circulatory health.
Industrial Application Areas
Due to its targeted antithrombotic properties, Leech Extract is a highly sought-after API for research and formulation in cardiovascular health, specifically targeting ischemic conditions, stroke prevention, and thrombosis management.
Leveraged for its ability to enhance microcirculation, it acts as a premium active additive in anti-aging, age-spot reduction, and eye care cosmetics, addressing hyperpigmentation caused by weakened peripheral blood flow.
Continuous optimization of our extraction methodology allows us to supply high-purity hirudin for advanced clinical research, mass-production of diagnostic reagents, and the development of next-generation hematology tools.
Standardized Production Process
Xi'an Tihealth guarantees batch-to-batch consistency through a rigorous, GMP-compliant manufacturing
1. Sustainable Cultivation & Induction:
Controlled rearing of select species, utilizing precise chemical induction to stimulate salivary secretion.
2. Cryogenic Processing:
Subjecting specimens to -20°C to -25°C to maximize salivary yield while preventing blood and impurity contamination
3. Chromatographic Purification:
Multi-stage filtration and purification to isolate crude hirudin peptides
4. Pharmaceutical Grade Refinement:
Advanced enzymatic processing to meet stringent heavy metal and microbiological limits
5. Lyophilization (Freeze-Drying):
Final drying under high vacuum to preserve the delicate biological activity (ATU) of the natural enzymes.
Frequently Asked Questions
Q: Can I specify the required biological activity (ATU/g) for my formulation?
A:Yes. Xi'an Tihealth offers customizable specifications ranging from 150 ATU/g up to highly refined 3000 ATU/g, depending on whether your application is cosmetic, nutritional, or pharmaceutical.
Q: Is your Leech Extract fully water-soluble?
A: Absolutely. Through advanced enzymatic hydrolysis and lyophilization, our extract powder maintains excellent water solubility, ensuring seamless integration into liquid formulations, serums, and injectables.
Q: What documentation accompanies bulk orders?
A: Every commercial dispatch includes a comprehensive QA package: a batch-specific Certificate of Analysis (COA), MSDS, Technical Data Sheet (TDS), and third-party testing reports confirming heavy metal compliance and the absence of pathogens.
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