L-Ergothioneine | CAS 497-30-3 | 99.9% HPLC | Pure L-Enantiomer
Product Source: Biological Fermentation
Content Specification: ≥ 99.5% (HPLC)
Chiral Purity: 100% L-Enantiomer (Specific Rotation ≥ +122°)
CAS Number: 497-30-3
Testing Method: HPLC
Product Packaging: 1kg / Aluminum foil bag ; 25kg / Pharmaceutical fiber drum
Product Storage: Sealed, protected from light, stored in a cool and dry place (2-8°C recommended for optimal long-term stability)
Shelf Life: 24 months
L-Ergothioneine (EGT) API | CAS 497-30-3 | 99.9% HPLC Ultra-High Purity
L-Ergothioneine (Molecular Formula: C9H15N3O2S) is a highly specialized, naturally occurring thiourea derivative of histidine, featuring a unique thiol (sulfhydryl) group. Xi'an Tihealth Biotechnology Co., Ltd. is a leading global B2B manufacturer and verified supply chain partner for this premium pharmaceutical-grade API. While the global market is compromised by low-tier synthetic alternates containing unstable racemic mixtures, Tihealth systematically shatters this bottleneck by delivering a 100% pure L-Enantiomer stereospecific matrix (+125.3° Specific Rotation), engineered for flawless cellular bio-recognition via the OCTN1 transporter. Validated by comprehensive batch chromatograms, our EGT delivers a magnificent peak purity of 99.9% via HPLC, acting as the ultimate protective API for elite anti-aging complexes and cellular longevity therapeutics.
⚠️ REGULATORY COMPLIANCE & MANUFACTURING NOTICE
Research Use Only (RUO) & B2B Formulation: This ultra-high-purity API is strictly supplied as a raw material for commercial manufacturing, third-party laboratory auditing, and advanced R&D compounding. It is not a finished dietary product intended for direct retail consumer ingestion.
Isomeric Integrity: Mathematically guaranteed 100% L-Enantiomer. Tihealth explicitly guarantees the absolute absence of biologically inert D-isomers and toxic racemic mixtures prevalent in unverified, low-tier synthetic analogs.
Technical Data Sheet (TDS) & Analytical Quality Control
| Analysis Item | Acceptable Specification | Result (Batch: NLEGT250301) |
|---|---|---|
| Product Identity / CAS | L-Ergothioneine / 497-30-3 | Conforms (IR / NMR) |
| Purity Trace (Assay) | ≥ 99.5% (HPLC-UV) | 99.9% |
| Specific Rotation [α]D20 | ≥ (+) 122° (Chiral Control) | +125.3° (100% L-Stereospecific) |
| Appearance Profile | White to off-white crystalline powder | White Crystalline Powder |
| Loss on Drying | ≤ 1.0% | 0.12% |
| Trace Heavy Metals (ICP-MS) | As < 2.0 ppm | Pb ≤ 10.0 ppm | As: 0.001 ppm | Pb: 0.030 ppm (ppb Level) |
Advanced Bioprocessing & Isolation Engineering
- Enantiomeric Stereospecific Control: Standard synthesis forms redundant D-enantiomers. Tihealth utilizes targeted enzymatic condensation coupled with chiral resolution engineering to guarantee an absolute, pure L-stereospecific compound (+125.3°) matching endogenous mammalian receptors.
- Vacuum Low-Temperature Crystallization: The volatile thiol ring architecture of EGT degrades violently under heat. Our facility enforces a multi-tier vacuum reduced-pressure crystallization loop inside inert chambers to eliminate oxidizing radicals and secure pristine white crystals at 99.9% purity.
- Solvatochromic Formulation Solubilization: Through dynamic micro-milling, we manage particle consistency to an explicit D90 threshold, empowering formulators to introduce high-concentration EGT matrices into clear aqueous liquids with 24-month color fastness without sediment blockages.
Evidence-Based Mechanisms & Target Sectors
Cellular Protection Mechanisms
1. OCTN1 Transporter Delivery: Features an exclusive, high-affinity cross-membrane vehicle in humans (OCTN1), forcefully concentrating EGT inside cells under severe oxidative stress.
2. Mitochondrial & DNA Defense: Segregates natively into the mitochondrial matrix to aggressively scavenge hydroxyl radicals and peroxynitrite, preserving telomere lengths.
3. MMP-1 Suppression: Down-regulates Matrix Metalloproteinase-1 transcription induced by UVA, safeguarding fibroblast matrix integrity and reversing photo-aging.
Industrial Formulation Sectors
♦ High-End Medical Cosmeceuticals: The gold standard active ingredient for elite anti-aging crèmes and night serums demanding profound UV protection.
♦ Cellular Longevity Supplements: Formulated into top-tier telomere-protection complexes and NAD+ synergy capsule lines.
♦ Clear Functional Beverages: Dissolves flawlessly in water bases without causing murky turbidity, enduring high-temperature flash pasteurization.
Packaging, Logistics & Secure Payment
Reliable B2B Supply Chain Solutions
From pilot R&D grams in vacuum-sealed foil bags up to mass industrial 100kg drums, we provide pharmaceutical-grade aseptic packaging and efficient global logistics with full CTD/DMF documentation for frictionless customs release.
Procurement & Formulation FAQ
The definitive distinction lies in cellular target accuracy. Ordinary antioxidants rely entirely on passive intercellular diffusion. L-Ergothioneine features a dedicated cross-membrane transporter (OCTN1 protein) that actively pulls EGT directly inside the mitochondrial core and nuclear space, making it a highly specific cellular shield.
Specific rotation is the primary defense against synthetic counterfeiting. Low-grade synthesis yields racemic structures where the D-isomer is inactive. By validating a specific rotation of +125.3° on our COA, Tihealth irrefutably establishes that our API is 100% pure, bioactive L-enantiomer.
Standard extracts containing unstable thiol compounds oxidize rapidly. Tihealth implements an advanced low-temperature vacuum crystallization process that fortifies the crystalline lattice. In aqueous bases, it displays exceptional photo-stability and heat resistance, maintaining transparency across its shelf life.
Tihealth's batch analytics demonstrate exceptional results: Arsenic (As), Cadmium (Cd), and Mercury (Hg) are tightly bounded at a remarkable 0.001 ppm (ppb level). This forensic cleanliness easily passes strict EU regulatory limits and California Proposition 65 audits.
Xi'an Tihealth Biotechnology Compliance Statement: High-purity active pharmaceutical ingredient (API). Strictly for commercial manufacturing and authorized laboratory application.
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